Mucoadhesive Drug Delivery System- An Overview
نویسندگان
چکیده
Mucoadhesive drug delivery systems extent the residence time of dosage form at site application or absorption. They facilitate an intimate touch shape with underlying absorption floor and accordingly enhance healing overall performance drug. These structures continue to be in near tissue, mucous membrane, liberating on movement action main a bioavailability growth each nearby systemic effect. The principal benefit this course for transport is that, via way means passes primary pass metabolism diverse capsules which are susceptible their hepatic first metabolism. This assessment provide short information approximately oral mucosal discussing structural function mucosa, mechanism mucoadhesion, theories well-known attention layout mucoadhesive buccal forms, permeation complements strategies side literature Survey System.
منابع مشابه
Mucoadhesive drug delivery system: An overview
Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT. Thus, mucoadhesive dosage forms are advantage...
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Among novel drug delivery systems, Buccal mucoadhesive systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. Buccal mucoadhes...
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Mucoadhesion is a field of current interest in the design of drug delivery systems. Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Mucoadhesive drug delivery system may be designed to enable prolonged residence time of the dosage form at the site of application or absorption and facilitate an intimate contact of the dosage for...
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Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diff...
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ژورنال
عنوان ژورنال: International Journal For Multidisciplinary Research
سال: 2023
ISSN: ['2582-2160']
DOI: https://doi.org/10.36948/ijfmr.2023.v05i03.3209